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Cell 173 , 16221635.e1614 (2018)

The typical symptoms of psoriasis are skin lesions resulting from epidermal hyperproliferation, increased angiogenesis, and accumulation of inflammatory cells (201)

12 Abnormally high levels of the neurofilament light chain protein in blood, a biomarker of damaged neurons, were found to start an average of 22 years before the median estimated age of symptom onset

Therefore, it is impossible to determine if IN GHK-Cu actually restored the aged hippocampus to a youthful transcriptomic state, or if it pushed the tissue into a novel, alternative compensatory state that simply happens to function better

\(wt\) stands for the UPDRS score of patients under treatment